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Heli J Lehtonen Selected Research

Hereditary leiomyomatosis and renal cell cancer

9/2011Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status.
7/2009Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer.
9/2007Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability.
5/2007Conventional renal cancer in a patient with fumarate hydratase mutation.
7/2006Analysis of fumarate hydratase mutations in a population-based series of early onset uterine leiomyosarcoma patients.
1/2006Distinct expression profile in fumarate-hydratase-deficient uterine fibroids.

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Heli J Lehtonen Research Topics

Disease

10Neoplasms (Cancer)
04/2012 - 01/2006
6Hereditary leiomyomatosis and renal cell cancer
09/2011 - 01/2006
3Carcinogenesis
06/2011 - 01/2006
3Hypoxia (Hypoxemia)
06/2011 - 01/2007
2Colorectal Neoplasms (Colorectal Cancer)
04/2012 - 03/2011
2Leiomyoma (Uterine Fibroids)
10/2011 - 01/2006
2Kidney Neoplasms (Kidney Cancer)
09/2011 - 05/2007
2Renal Cell Carcinoma (Grawitz Tumor)
07/2009 - 06/2008
1Sarcoma (Soft Tissue Sarcoma)
12/2012
1Microsatellite Instability
04/2012
1Ataxia Telangiectasia (Louis Bar Syndrome)
07/2011
1Hodgkin Disease (Hodgkin's Disease)
07/2011
1Pituitary Neoplasms (Pituitary Adenoma)
10/2010
1Leiomyomatosis
06/2008
1Genomic Instability
09/2007
1Retinoblastoma (Glioblastoma, Retinal)
08/2006
1Prostatic Neoplasms (Prostate Cancer)
08/2006
1Leiomyosarcoma
07/2006

Drug/Important Bio-Agent (IBA)

6Fumarate Hydratase (Fumarase)IBA
09/2011 - 01/2006
5Proteins (Proteins, Gene)FDA Link
12/2012 - 09/2007
3EnzymesIBA
09/2011 - 01/2006
2Calcibiotic Root Canal SealerIBA
04/2012 - 03/2011
2FumaratesIBA
09/2007 - 01/2006
1ActomyosinIBA
12/2012
1Mediator ComplexIBA
10/2011
1Biomarkers (Surrogate Marker)IBA
09/2011
1Serine (L-Serine)FDA Link
07/2011
1Nuclear Proteins (Protein, Nuclear)IBA
07/2011
1Glucose (Dextrose)FDA LinkGeneric
06/2011
1Transcription Factors (Transcription Factor)IBA
06/2011
1Paclitaxel (Taxol)FDA LinkGeneric
03/2011
1Pharmaceutical PreparationsIBA
03/2011
1Messenger RNA (mRNA)IBA
03/2011
1aryl hydrocarbon receptor-interacting proteinIBA
10/2010
1Growth Hormone (Somatotropin)IBA
10/2010
1Aryl Hydrocarbon Receptor Nuclear TranslocatorIBA
10/2010
1Formaldehyde (Formol)FDA Link
07/2009
1DNA (Deoxyribonucleic Acid)IBA
07/2009
1ParaffinIBA
07/2009
1Succinic Acid (Succinate)IBA
09/2007
1Succinate Dehydrogenase (Fumarate Reductase)IBA
09/2007
1Hypoxia-Inducible Factor 1IBA
09/2007
14-trifluoromethylsalicylic acid (HTB)IBA
01/2007
1Retinoblastoma ProteinIBA
08/2006
1Small Interfering RNA (siRNA)IBA
08/2006

Therapy/Procedure

1Ligation
06/2008